US agency to lift ban on funding human–animal hybrids

gettyimages-80133388_webSince September 2015, researchers have been banned from receiving funding from the US National Institutes of Health (NIH) for adding human stem cells to animal embryos, creating blends called chimaeras. But a proposal by the NIH released on 4 August would lift the funding moratorium, except for certain situations. It would also set up a panel to review the ethics and oversight of grant applications.

The new rules shorten the developmental window during which human cells can be introduced into non-human primate embryos, disallowing it before the stage of development in which the central nervous system begins to form. This is intended to limit the number of human cells that would make up the chimaera’s brain. They also prohibit breeding animals that contain human cells, so as to prevent a human-like embryo from growing in a non-human womb or the birth of an animal that is more humanized than its parents.

Chimaeras are a growing area of research. Currently, researchers use them to study early embryonic development and to create animal models of human diseases. But one major goal is to engineer animals to grow human organs. The organs could later be harvested from the adult animal and used for transplantation into a patient.

The NIH’s rule is now open for public comment for 30 days, after which the agency will issue a final rule and lift the moratorium.

Read the full article in Nature

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